Description

Bryostatin 3 is a potent, naturally occurring macrocyclic lactone isolated from marine bryozoans, with the CAS registry number 143370-84-7. This compound is of significant interest for its unique biological activity as a modulator of protein kinase C (PKC), making it a critical research tool in oncology and neuroscience. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in the development of novel cancer therapeutics and the study of cellular signaling pathways.

Application

• Pharmaceutical Research & Development: As a lead compound or reference standard in the discovery of novel anti-cancer agents targeting protein kinase C (PKC) isoforms.
• Oncology Studies: Investigation of its effects on tumor cell proliferation, apoptosis, and differentiation in various cancer cell lines and preclinical models.
• Neuroscience Research: Exploration of its potential neuroprotective and memory-enhancing properties in models of neurodegenerative diseases like Alzheimer's.
• Biochemical Assay Development: Use as a high-purity standard or probe in enzymatic assays to study PKC activity and inhibition.
• Academic & Clinical Research: Fundamental research into cell signaling mechanisms, immune modulation, and combination therapy strategies.

Basic Information

Product Name	Bryostatin 3
CAS No.	143370-84-7
Molecular Formula	C45H68O17
Molecular Weight	881.0 g/mol
Synonyms	Bryostatin-3; Bryostatin C; NSC 339555; (1S,3S,4S,5R,7S,8S,9R,14S,15R,17S,18S,20R,21S)-21-[(1R)-1-Hydroxyethyl]-8,20-dimethoxy-4,7,18-trimethyl-10-methylidene-23-oxa-11,24-dioxahexacyclo[15.7.1.01,15.03,14.05,9.017,21]pentacosa-12,22-dione-2,6,16-trione
EINECS	Contact for details

Quality Control

Our Bryostatin 3 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.