Description

Ac-Yvad-Cho CAS NO 143313-51-3 is a high-purity, synthetic peptide substrate specifically designed for biochemical research and pharmaceutical development. This compound is a critical tool for studying caspase-1 (interleukin-1β converting enzyme, ICE) activity and its role in inflammatory and apoptotic pathways. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic research sectors who require reliable and consistent enzyme substrates for assay development and drug discovery.

Application

• Caspase-1 Enzyme Assays: Primary fluorogenic or colorimetric substrate for measuring ICE (Interleukin-1β Converting Enzyme) activity in vitro.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel caspase-1 inhibitors for anti-inflammatory therapeutics.
• Biochemical Research: Fundamental tool for investigating the mechanisms of pyroptosis and inflammation in cellular and molecular biology studies.
• Diagnostic Kit Development: A key component in the formulation of diagnostic kits for monitoring caspase-1 related disease states.
• Quality Control (QC) Testing: Employed in QC laboratories of biopharmaceutical companies to validate the activity of recombinant caspase-1 enzymes.

Basic Information

Product Name	Ac-Yvad-Cho
CAS No.	143313-51-3
Molecular Formula	C27H38N6O8
Molecular Weight	574.63 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-CHO; N-Acetyl-Tyr-Val-Ala-Asp-al; Acetyl-Tyr-Val-Ala-Asp-aldehyde; Caspase-1 Substrate, Ac-YVAD-CHO; ICE Inhibitor I, Ac-YVAD-CHO; Interleukin-1β Converting Enzyme Inhibitor
EINECS	Contact for details

Quality Control

Every batch of Ac-Yvad-Cho is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, MS, and NMR, to ensure high purity and batch-to-batch consistency essential for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and assay results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.