Description

5,10-Methylenetetrahydro-5-Deazafolic Acid is a specialized folate analog and a key intermediate in the synthesis of novel enzyme inhibitors and pharmaceutical compounds. Its unique deaza structure makes it a valuable scaffold for research into antifolate agents and targeted therapeutics. This high-purity chemical is essential for pharmaceutical R&D, academic research, and the development of biochemical tools.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antifolate drugs and enzyme inhibitors targeting folate-dependent pathways.
• Biochemical Research: Used as a reference standard and tool compound in studies of folate metabolism, thymidylate synthase, and dihydrofolate reductase (DHFR).
• Anticancer Agent Development: Serves as a precursor in the research and development of potential chemotherapeutic agents.
• Enzyme Inhibition Studies: Employed to investigate the mechanism of action and binding affinity of deazafolate analogs against specific enzymatic targets.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for fundamental and applied life science research.

Basic Information

Product Name	5,10-Methylenetetrahydro-5-Deazafolic Acid
CAS No.	143234-78-0
Molecular Formula	C20H23N7O6
Molecular Weight	457.44 g/mol
Synonyms	5,10-CH2-THF-5-Deaza; 5,10-Methylene-5,6,7,8-tetrahydro-5-deazafolic acid; 5-Deaza-5,10-methylenetetrahydrofolate; NSC 339313; 5,10-Methylene-5-deazatetrahydrofolate; 5,10-CH2-5-deazaTHF
EINECS	Contact for details

Quality Control

Our 5,10-Methylenetetrahydro-5-Deazafolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.