Description

Alpha4 Integrin CAS NO 143198-26-9 is a high-purity, synthetic peptide inhibitor specifically designed to target the α4β1 integrin receptor (VLA-4). This compound is a critical research tool for studying cell adhesion, migration, and signaling pathways in immunology and oncology. It is essential for scientists and pharmaceutical developers in preclinical research, drug discovery, and diagnostic assay development, particularly for investigating inflammatory diseases, autoimmune disorders, and cancer metastasis.

Application

• Biomedical Research: Used as a specific antagonist to study the role of VLA-4 in leukocyte adhesion and trafficking in inflammatory models.
• Drug Discovery Screening: Serves as a reference standard and positive control in high-throughput screening assays for novel anti-inflammatory or anti-metastatic therapeutics.
• Immunology Studies: Applied in vitro to block α4β1-mediated cell adhesion to VCAM-1 and fibronectin, elucidating mechanisms in diseases like multiple sclerosis, asthma, and rheumatoid arthritis.
• Cancer Research: Investigates the inhibition of tumor cell migration, invasion, and angiogenesis mediated by α4 integrins in metastatic cancers.
• Stem Cell Research: Utilized to modulate the interaction of hematopoietic stem cells with the bone marrow niche via the VLA-4 receptor.
• Diagnostic Development: Acts as a key component in developing cell-based or biochemical assays to quantify integrin activity or screen for inhibitory compounds.

Basic Information

Product Name	Alpha4 Integrin CAS NO 143198-26-9
CAS No.	143198-26-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α4 Integrin Inhibitor; VLA-4 Antagonist; BIO-1211; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]pentanoic acid; Cyclic Peptide Inhibitor of Alpha4 Beta1 Integrin
EINECS	Contact for details

Quality Control

Our Alpha4 Integrin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) with detailed specifications for traceability and compliance with research-grade standards. Our quality commitment ensures reliable, reproducible performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The product should be handled in a controlled environment to maintain its integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.