Description

Ilomastat CAS NO 142880-36-2 is a potent and selective synthetic inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinases like MMP-2 and MMP-9. This compound is a critical research tool for studying extracellular matrix remodeling, tissue degradation, and related pathological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on oncology, inflammation, and fibrosis.

Application

• Biomedical Research: A key reagent for investigating the role of MMP-2 and MMP-9 in cancer metastasis, angiogenesis, and tumor progression.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening assays for novel MMP inhibitors.
• Inflammation Studies: Applied in models of arthritis, atherosclerosis, and other inflammatory diseases where MMP activity is dysregulated.
• Fibrosis Research: Utilized to study the mechanisms of tissue scarring in cardiac, pulmonary, and hepatic fibrosis.
• Neuroscience Research: Investigates MMP involvement in blood-brain barrier disruption, neuroinflammation, and neurodegenerative conditions.
• Wound Healing Studies: Explores the balance of matrix degradation and synthesis in tissue repair and regeneration models.

Basic Information

Product Name	Ilomastat
CAS No.	142880-36-2
Molecular Formula	C₂₀H₂₈N₄O₄
Molecular Weight	388.46 g/mol
Synonyms	GM 6001; Galardin; N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide; MMP Inhibitor III; MMP-2/MMP-9 Inhibitor; Ilomastat (GM6001); (R)-N4-Hydroxy-N1-[(S)-1-(1H-indol-3-ylmethyl)-2-(methoxycarbonylamino)-2-oxoethyl]-2-isobutylsuccinamide
EINECS	Contact for details

Quality Control

Our Ilomastat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, assay results, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.