Description

Enlimomab CAS NO 142864-19-5 is a monoclonal antibody designed to target intercellular adhesion molecule-1 (ICAM-1). This compound is significant for its role as a potent anti-inflammatory agent, specifically inhibiting leukocyte adhesion and migration, which are key processes in inflammatory and autoimmune responses. It is primarily required by pharmaceutical research and development teams focused on novel therapeutics for conditions such as stroke, rheumatoid arthritis, and organ transplant rejection.

Application

• Pharmaceutical Research & Development: As a key biological tool for studying inflammatory pathways and leukocyte-endothelial interactions.
• Preclinical Drug Development: For in vitro and in vivo efficacy and safety testing of anti-inflammatory strategies.
• Biochemical Assay Standard: Used as a reference standard in ELISA, flow cytometry, and other immunoassays targeting ICAM-1.
• Therapeutic Candidate Evaluation: Investigation into its potential for treating ischemic stroke, acute lung injury, and other inflammation-mediated conditions.

Basic Information

Product Name	Enlimomab
CAS No.	142864-19-5
Molecular Formula	C6440H9916N1704O2016S44
Molecular Weight	Approx. 145 kDa
Synonyms	Anti-ICAM-1 Monoclonal Antibody; Enlimomab; BIRR 1; Anti-CD54; Anti-Intercellular Adhesion Molecule 1; Murine anti-human ICAM-1 antibody; BIRR-1; R 6.5
EINECS	Contact for details

Quality Control

Our Enlimomab is produced under stringent conditions to ensure high purity and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, size-exclusion HPLC, and endotoxin level analysis, to confirm identity, purity, and safety. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant when applicable.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (SEC-HPLC)	≥ 95% (Monomer)
Protein Content (UV Absorbance)	≥ 1.0 mg/vial
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Cell Adhesion Assay)	IC50 provided on COA
Solubility	Soluble in PBS or sterile water for injection

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.