Description

4-Bromo-2-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors, where it is used to introduce fluorinated motifs that can dramatically alter a compound's bioavailability, stability, and activity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the trifluoromethyl and halogen groups contribute to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart desired characteristics such as chemical resistance, thermal stability, or specific optical properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings for carbon-carbon bond formation.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science R&D for creating novel compound libraries.

Basic Information

Product Name	4-Bromo-2-Fluorobenzotrifluoride
CAS No.	142808-15-9
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	1-Bromo-4-fluoro-2-(trifluoromethyl)benzene; 2-Fluoro-4-bromobenzotrifluoride; 4-Bromo-2-fluoro-α,α,α-trifluorotoluene; 4-Bromo-2-fluoro-α,α,α-trifluoromethylbenzene; 4-Bromo-2-fluorobenzylidene trifluoride; (4-Bromo-2-fluorophenyl)trifluoromethane; Benzene, 1-bromo-4-fluoro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.75 g/cm³
Boiling Point	~185-190°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.