Description

Dendrotoxin A CAS NO 142661-42-5 is a potent, high-purity neurotoxin peptide isolated from the venom of the Eastern Green Mamba (*Dendroaspis angusticeps*). This compound is a critical research tool for studying voltage-gated potassium (Kv) channels, offering high specificity and affinity. It is essential for researchers and developers in neuroscience, pharmacology, and toxicology, facilitating advanced studies in ion channel function, neurological disorders, and drug discovery.

Application

• Neuroscience Research: A selective blocker of specific Kv1 subfamily potassium channels (e.g., Kv1.1, Kv1.2), used to investigate neuronal excitability and synaptic transmission.
• Ion Channel Pharmacology: Serves as a reference standard and pharmacological tool for characterizing potassium channel subtypes and screening novel channel modulators.
• Drug Discovery & Development: Used in target validation and assay development for neurological and cardiovascular drug candidates targeting potassium channels.
• Toxicology Studies: Employed as a model toxin to study the mechanisms of venom action and to develop antivenom or therapeutic countermeasures.
• Biochemical Reagent: Utilized in the purification and study of potassium channel proteins and receptor complexes.
• Academic & Institutional Research: A key reagent for fundamental research in cellular physiology and molecular biology laboratories worldwide.

Basic Information

Product Name	Dendrotoxin A
CAS No.	142661-42-5
Molecular Formula	C184H282N52O53S7
Molecular Weight	~4180 g/mol
Synonyms	Dendrotoxin I; DTX-I; Toxin I (Dendroaspis angusticeps); Dendrotoxin K; Potassium channel toxin α-DTx; ShK-like toxin; Neurotoxin Dendrotoxin A; Dendroaspis Toxin
EINECS	Contact for details

Quality Control

Our Dendrotoxin A is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency (specific activity), and identity confirmation. We adhere to rigorous quality testing protocols to guarantee consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Protein Content (UV)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.