Description

Zaragozic Acid A is a potent, naturally occurring inhibitor of squalene synthase, a key enzyme in the sterol biosynthesis pathway. This compound is of significant interest in biochemical and pharmacological research for its ability to modulate cholesterol and ergosterol production. It serves as a critical research tool for scientists in pharmaceutical development, metabolic disorder studies, and antifungal agent discovery.

Application

• Pharmaceutical Research: A key reference standard and tool compound for investigating cholesterol biosynthesis inhibitors and developing novel lipid-lowering agents.
• Antifungal Agent Development: Used in studies targeting ergosterol synthesis in fungi, aiding in the discovery of new antifungal therapies.
• Metabolic Pathway Analysis: Employed in biochemical assays to study the mevalonate pathway and the role of squalene synthase in cellular metabolism.
• Enzyme Inhibition Studies: Serves as a specific, high-affinity inhibitor for characterizing squalene synthase activity and kinetics in vitro.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in biochemistry, cell biology, and medicinal chemistry.
• Biotech R&D: Supports discovery programs in biotechnology companies focused on metabolic diseases, cardiovascular health, and infectious diseases.

Basic Information

Product Name	Zaragozic Acid A
CAS No.	142561-96-4
Molecular Formula	C30H40O8
Molecular Weight	528.64 g/mol
Synonyms	Squalestatin 1; Zaragozic Acid; L-731,120; ZGA; Squalene Synthase Inhibitor; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[[(1S,2S,3R,4S,6S,7R,8R)-2,3,7-trihydroxy-8-[(1E)-3-hydroxy-3-methyloct-1-en-1-yl]-1,4-dimethyl-1,2,3,4,4a,6,7,8-octahydro-1,6-methanoanthracen-9-yl]oxy]oxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Zaragozic Acid A is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems support research conducted under GLP (Good Laboratory Practice) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be kept in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.