Description

L-690,330 is a potent and selective inhibitor of inositol monophosphatase (IMPase), a key enzyme in the phosphatidylinositol signaling pathway. This compound matters as a critical research tool for studying cellular signaling cascades, lithium's mechanism of action, and potential therapeutic pathways for bipolar disorder and related neurological conditions. Researchers in pharmaceutical R&D, neuroscience, and biochemistry need this high-purity biochemical for target validation, enzyme kinetics studies, and pathway analysis.

Application

• Neuroscience Research: Used to investigate the role of the inositol depletion hypothesis in the pathophysiology and treatment of bipolar disorder.
• Enzymology Studies: Serves as a selective inhibitor for in vitro and in-cell assays to study IMPase enzyme kinetics and function.
• Pharmaceutical Screening: Employed as a reference standard and tool compound in high-throughput screening campaigns for novel mood stabilizers.
• Cell Signaling Pathway Analysis: A key reagent for modulating the phosphatidylinositol (PI) cycle to study downstream effects on calcium release and protein kinase C (PKC) activation.
• Lithium Mechanism Research: Used in comparative studies to elucidate the specific molecular targets of lithium therapy.

Basic Information

Product Name	L-690,330
CAS No.	142523-38-4
Molecular Formula	C₁₀H₁₃N₅O₃S
Molecular Weight	283.31 g/mol
Synonyms	L690330; L 690330; 2,4-Diamino-6-[3-(phenylsulfanyl)propyl]-5-pyrimidinecarbonitrile; Thionophosphoric Acid Ester Inhibitor; Inositol Monophosphatase Inhibitor; IMPase Inhibitor L-690,330
EINECS	Contact for details

Quality Control

Our L-690,330 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.