Description

Calicheamicin T CAS NO 142518-72-7 is a potent enediyne antitumor antibiotic belonging to the calicheamicin family. This compound is of significant interest for its role as a key payload in antibody-drug conjugates (ADCs), enabling targeted cancer therapy. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic research institutions focused on oncology drug development and advanced bioconjugation strategies.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in targeted cancer therapies, leveraging its high potency.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer treatments.
• Bioconjugation Studies: Employed in developing and optimizing linker-payload technologies for next-generation targeted therapeutics.
• Mechanistic Studies: Utilized to investigate DNA cleavage mechanisms and cellular apoptosis pathways.
• Pharmaceutical Synthesis: Acts as a critical intermediate in the synthesis of more complex enediyne-based therapeutic agents.

Basic Information

Product Name	Calicheamicin T
CAS No.	142518-72-7
Molecular Formula	C55H74IN3O21S4
Molecular Weight	1368.36 g/mol
Synonyms	Calicheamicin T; Calicheamicin θ; Calicheamicin Theta; LDP-T; N-Acetyl-γ-calicheamicin; γ1I-Calicheamicin; Antibiotic LL 33288; (1S,2R,3S,5S,8S,10S,11S,12R,14S,32S,33R,35R,36S,37S,38R)-37-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyl-5-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-33,36,38-trihydroxy-11-iodo-2,5,8,14,32-pentamethyl-4,9,13,31,34,39-hexaoxaheptacyclo[30.6.1.13,8.110,14.115,19.01,35.020,29]nonatriaconta-15,17,19(39),20,22,24,26,28-octaene-12-carbothioate
EINECS	Contact for details

Quality Control

Our Calicheamicin T is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.