Description

Squalestatin 3 is a potent and selective inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical research tool for studying lipid metabolism, cellular signaling, and the development of novel therapeutic agents targeting hypercholesterolemia. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in metabolic disease and oncology research.

Application

• Biochemical Research: A standard inhibitor for in vitro and cell-based assays to study the mevalonate pathway and cholesterol synthesis.
• Pharmaceutical Development: Used as a reference compound and pharmacological tool in the discovery of novel cholesterol-lowering drugs and anti-cancer agents.
• Mechanistic Studies: Investigating the role of isoprenoid intermediates in cell proliferation, differentiation, and apoptosis.
• Metabolic Disorder Research: Exploring the biochemical basis of diseases related to lipid dysregulation.
• Enzyme Kinetics: Characterizing the activity and inhibition profile of squalene synthase.

Basic Information

Product Name	Squalestatin 3
CAS No.	142505-92-8
Molecular Formula	C29H48O6
Molecular Weight	492.69 g/mol
Synonyms	Zaragozic Acid C; Squalestatin 1; Zaragozic Acid A; Squalestatin; Zaragozic Acid; Squalene Synthase Inhibitor; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[[(1S,2S,3R,5S,7S,9S)-2,3,5,9-tetrahydroxy-7-[(1E,3E,5E,7E)-8-methyl-3,5,7-trimethylnona-1,3,5,7-tetraenyl]-1-adamantyl]methoxy]oxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Squalestatin 3 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.