Description

Squalestatin 2 CAS NO 142505-91-7 is a potent and selective inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical research tool for studying lipid metabolism, cellular signaling, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disorders, oncology, and antifungal drug discovery.

Application

• Biochemical Research: Used as a specific inhibitor to study the mevalonate pathway and isoprenoid biosynthesis in cell culture and enzymatic assays.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery of novel cholesterol-lowering and antifungal agents.
• Metabolic Disorder Studies: Applied in research models to investigate diseases related to dysregulated cholesterol and lipid homeostasis.
• Oncology Research: Explored for its potential effects on cancer cell proliferation due to its role in inhibiting protein prenylation.
• Academic & Institutional Labs: A key reagent for fundamental research in biochemistry, molecular biology, and pharmacology.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related substances.

Basic Information

Product Name	Squalestatin 2
CAS No.	142505-91-7
Molecular Formula	C29H44N2O5
Molecular Weight	500.68 g/mol
Synonyms	Squalestatin 2; Zaragozic Acid A; ZA-A; Squalestatin 1 (Note: Often used interchangeably but structurally distinct); L-669,262; Squalene Synthase Inhibitor; 2,8-Dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid derivative
EINECS	Contact for details

Quality Control

Every batch of Squalestatin 2 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) including HPLC purity, NMR confirmation, and residual solvent analysis is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.