Description

L-701,324 is a high-purity, non-competitive antagonist selective for the glycine site of the NMDA receptor complex. This compound is a critical research tool for neuroscience and pharmacology, enabling precise modulation of glutamatergic signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) investigating neurological disorders, synaptic plasticity, and novel therapeutic targets.

Application

• Neuroscience Research: Used as a selective tool compound to study the role of NMDA receptors in synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Pharmacological Studies: Employed in in vitro and in vivo models to investigate the glycine binding site and its implications for excitotoxicity and neuroprotection.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the screening and development of novel neuroprotective agents and treatments for stroke, traumatic brain injury, and neurodegenerative diseases.
• Biochemical Assays: Utilized in receptor binding assays and functional tests to characterize compound interactions and potency at the NMDA receptor glycine site.
• Academic & Institutional Research: Supports fundamental research into glutamate receptor function, neuronal communication, and the molecular basis of learning and memory.

Basic Information

Product Name	L-701,324
CAS No.	142326-59-8
Molecular Formula	C₁₇H₁₃ClN₄O₂
Molecular Weight	340.76 g/mol
Synonyms	7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone; L 701324; L-701,324; MDL-105,519; 7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one; 3-(3-Phenoxyphenyl)-7-chloro-4-hydroxy-1H-quinolin-2-one; Glycine site NMDA receptor antagonist L-701324; NMDA receptor glycine site antagonist
EINECS	Contact for details

Quality Control

Our L-701,324 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.