Description

Kenpaullone is a potent and selective small-molecule inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β). This compound is a critical research tool for studying cell cycle regulation, signal transduction pathways, and neurodegenerative diseases. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery and biochemical research.

Application

• Biochemical Research: Used as a selective inhibitor to study the roles of CDKs (e.g., CDK1, CDK2, CDK5) and GSK-3β in cellular processes.
• Neurodegenerative Disease Studies: Investigated in research models for Alzheimer's disease, Parkinson's disease, and other tauopathies due to its GSK-3β inhibitory activity.
• Oncology Research: Employed in cancer research to understand cell cycle dysregulation and to explore potential therapeutic avenues targeting CDKs.
• Stem Cell Research: Applied in studies focusing on Wnt/β-catenin signaling pathways, which are crucial for stem cell maintenance and differentiation.
• Drug Discovery & Development: Serves as a lead compound or a pharmacological tool for validating new targets in preclinical development pipelines.
• Academic & Institutional Laboratories: A standard reagent for graduate and postdoctoral research in molecular biology and pharmacology departments.

Basic Information

Product Name	Kenpaullone
CAS No.	142273-20-9
Molecular Formula	C16H10BrN3O
Molecular Weight	340.18 g/mol
Synonyms	9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; Kenpaullone; NSC 664704; 9-Bromopaullone; GSK-3β Inhibitor IX; CDK Inhibitor; 1-Azapaullone
EINECS	Contact for details

Quality Control

Our Kenpaullone CAS NO 142273-20-9 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere or desiccated upon opening for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.