Description

Paullone CAS NO 142273-18-5 is a synthetic organic compound belonging to the paullone class of heterocyclic molecules, recognized for its role as a potent and selective inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3). This compound is a critical research tool in biochemical and pharmacological studies, enabling the investigation of cell cycle regulation, signal transduction pathways, and neurodegenerative disease mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and CNS drug discovery.

Application

• Biochemical Research: Used as a selective kinase inhibitor to study CDK and GSK-3 signaling pathways in vitro.
• Pharmaceutical R&D: Serves as a key reference standard and pharmacophore in the discovery and development of novel anti-cancer and neuroprotective agents.
• Cell Biology Studies: Employed to induce cell cycle arrest and investigate mechanisms of apoptosis and proliferation in various cell lines.
• Neuroscience Research: Applied in models of Alzheimer's disease and other tauopathies to study the inhibition of GSK-3β and its effect on tau protein phosphorylation.
• Chemical Probe Development: Acts as a scaffold for the synthesis of analogs to explore structure-activity relationships (SAR) for improved selectivity and potency.
• Academic & Institutional Research: A fundamental reagent for graduate and post-doctoral research projects in medicinal chemistry and molecular biology.

Basic Information

Product Name	Paullone
CAS No.	142273-18-5
Molecular Formula	C₁₄H₁₀N₂O
Molecular Weight	222.24 g/mol
Synonyms	9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; Kenpaullone; NSC 664704; 9-Bromopaullone; GSK-3 Inhibitor IX; CDK Inhibitor; 9-Bromo-7,12-dihydro-6H-indolo[3,2-d][1]benzazepin-6-one
EINECS	Contact for details

Quality Control

Our Paullone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our standards align with research-grade material specifications for reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.