Description

n-Hydroxy-2-Amino-3,8-Dimethylimidazo(4,5-F)Quinoxaline is a heterocyclic aromatic amine of significant interest in biochemical and toxicological research. This compound matters as a key reference standard and metabolite in studies investigating the formation, detection, and biological impact of mutagenic compounds derived from cooked foods. It is primarily needed by research institutions, analytical laboratories, and pharmaceutical companies focused on food safety, carcinogenesis, and the development of analytical methods for heterocyclic amines.

Application

• Analytical Reference Standard: Used as a high-purity calibrant in HPLC, LC-MS, and GC-MS for the accurate quantification of heterocyclic amines in complex matrices.
• Metabolite and Biomarker Research: Serves as a critical metabolite standard in studies exploring the metabolic activation, detoxification pathways, and DNA adduct formation of related food-borne mutagens.
• Toxicological Studies: Employed in in vitro and in vivo assays to investigate genotoxicity, mutagenicity, and the carcinogenic potential of imidazoquinoxaline derivatives.
• Food Safety and Quality Control: Essential for developing and validating analytical methods to monitor and control the levels of potentially harmful amines in processed meat and other cooked food products.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of novel derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	n-Hydroxy-2-Amino-3,8-Dimethylimidazo(4,5-F)Quinoxaline
CAS No.	142038-28-6
Molecular Formula	C12H11N5O
Molecular Weight	241.25 g/mol
Synonyms	2-Amino-3,8-dimethylimidazo[4,5-f]quinoxalin-N-oxide; 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline N-oxide; 3,8-DiMeIQx N-oxide; N-Hydroxy-3,8-DiMeIQx; 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline 1-oxide; 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 1-oxide; HA-3,8-DiMeIQx; N-OH-3,8-DiMeIQx
EINECS	Contact for details

Quality Control

Our n-Hydroxy-2-Amino-3,8-Dimethylimidazo(4,5-F)Quinoxaline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and structural verification by spectroscopic methods, to ensure it meets the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a desiccated environment after opening to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.