Description

Biotinylarginylchloromethane CAS NO 142009-29-8 is a specialized, high-purity biochemical reagent designed for advanced proteomics and enzyme inhibition research. This compound is a potent and irreversible inhibitor of trypsin-like serine proteases, serving as a critical tool for studying enzyme kinetics, substrate specificity, and cellular signaling pathways. It is essential for researchers and manufacturers in the fields of pharmaceutical development, life sciences, and diagnostic reagent production.

Application

• Protease Inhibition Studies: As a mechanism-based inhibitor for trypsin, thrombin, plasmin, and other serine proteases in biochemical assays.
• Pharmaceutical R&D: Used in the development and screening of novel therapeutic agents targeting protease-related diseases.
• Diagnostic Reagent Manufacturing: A key component in the formulation of diagnostic kits for coagulation and fibrinolysis analysis.
• Cell Biology & Signal Transduction Research: Employed to elucidate the role of specific proteases in cellular processes and disease models.
• Bioconjugation & Affinity Labeling: The biotin moiety allows for streptavidin-based detection, purification, and imaging applications.

Basic Information

Product Name	Biotinylarginylchloromethane
CAS No.	142009-29-8
Molecular Formula	C18H33ClN6O4S
Molecular Weight	465.01 g/mol
Synonyms	Biotin-Arg-CH2Cl; Biotinyl-arginyl-chloromethane; B-Arg-CH2Cl; Biotinylated arginine chloromethyl ketone; (2S)-5-[[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl]-N-[(1S)-5-(chloroamino)-1-[[(diaminomethylidene)amino]methyl]pentyl]glycinamide; BACMK; Protease Inhibitor (Biotinylated)
EINECS	Contact for details

Quality Control

Our Biotinylarginylchloromethane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by mass spectrometry, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.