Description

5-Fluoro-2-Methylbenzotrifluoride is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a fluorine atom and a trifluoromethyl group, makes it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups improve lipophilicity and biological activity.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystals for advanced display technologies (LCDs).
• Organic Electronics: Intermediate in the production of materials for organic light-emitting diodes (OLEDs) and semiconductor layers.
• Polymer Modification: Serves as a monomer or modifier to introduce fluorine into polymers, enhancing chemical resistance, thermal stability, and lowering surface energy.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	5-Fluoro-2-Methylbenzotrifluoride
CAS No.	141872-92-6
Molecular Formula	C9H6F4
Molecular Weight	190.14 g/mol
Synonyms	1-Fluoro-2-methyl-5-(trifluoromethyl)benzene; 2-Methyl-5-fluorobenzotrifluoride; α,α,α-Trifluoro-5-fluoro-2-methyltoluene; 5-Fluoro-α,α,α-trifluoro-o-xylene; 5-Fluoro-2-(trifluoromethyl)toluene; 2-Methyl-α,α,α,5-tetrafluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-Methylbenzotrifluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Our products undergo rigorous quality testing, including GC, HPLC, and NMR analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is 2-25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.30 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.