Description

3,5-Difluorobenzyl Bromide is a versatile and highly reactive organobromine building block characterized by its benzyl bromide core flanked by fluorine substituents. This compound is critical for introducing the 3,5-difluorobenzyl moiety into complex molecular architectures, enabling precise modulation of electronic and steric properties. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable synthetic precursors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, CNS-active compounds, and other fluorinated drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the difluorobenzyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis, leveraging fluorine's unique electronic effects.
• Material Science: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to fine-tune solubility and optoelectronic properties.
• Chemical Biology & Proteomics: Useful for creating affinity probes, enzyme inhibitors, and bioconjugation reagents for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs serving clients in life sciences and specialty chemicals.

Basic Information

Product Name	3,5-Difluorobenzyl Bromide
CAS No.	141776-91-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-(Bromomethyl)-3,5-difluorobenzene; (3,5-Difluorophenyl)methyl Bromide; α-Bromo-3,5-difluorotoluene; 3,5-Difluorobenzylbromide; 3,5-Difluoro-α-bromotoluene; 3,5-Difluorophenylmethyl Bromide; 3,5-Difluorobenzyl Bromide; 3,5-Difluorobenzyl Bromide (stabilized with Silver)
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzyl Bromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support compliance with cGMP, ISO, and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.