Description

α-(1,7-Diaza-5-(α-(Phenylmethylamino)Phenylmethyl)-2,6-Dioxobicyclo(5.4.0)Undecan-8-Yl)Glycyl-Isoleucyl-Argininyl Chloromethyl Ketone is a specialized, high-purity peptide-based chloromethyl ketone inhibitor designed for advanced biochemical research. This compound is critical for studying and modulating the activity of specific serine proteases due to its potent and irreversible inhibition mechanism. It is primarily utilized by pharmaceutical researchers, biochemists, and academic institutions engaged in proteomics, enzyme kinetics, and the development of novel therapeutic agents.

Application

• Protease Inhibition Studies: Acts as a potent, irreversible active-site inhibitor for characterizing serine protease function and mechanism.
• Biochemical Research Reagent: Used in enzymatic assays to investigate substrate specificity, catalytic pathways, and inhibition kinetics.
• Pharmaceutical Development: Serves as a key intermediate or tool compound in the discovery and optimization of novel protease-targeted drugs.
• Proteomics & Signal Transduction: Employed to dissect complex proteolytic cascades in cellular signaling and disease pathways.
• Academic & Institutional Research: A vital tool for universities and research institutes focusing on enzymology and structural biology.
• Quality Control Standards: Can be used as a reference standard in analytical method development for related pharmaceutical compounds.

Basic Information

Product Name	α-(1,7-Diaza-5-(α-(Phenylmethylamino)Phenylmethyl)-2,6-Dioxobicyclo(5.4.0)Undecan-8-Yl)Glycyl-Isoleucyl-Argininyl Chloromethyl Ketone
CAS No.	141650-30-8
Molecular Formula	C41H58ClN9O6
Molecular Weight	808.41 g/mol
Synonyms	Boc-D-Phe-Pro-Arg-CH2Cl; D-Phe-Pro-Arg chloromethyl ketone (Boc-protected); Protease Inhibitor 141650-30-8; Arg-CH2Cl derivative; Serine protease inhibitor; Thrombin inhibitor analog; Peptidyl chloromethyl ketone; Bicyclic peptide inhibitor
EINECS	Contact for details

Quality Control

Our α-(1,7-Diaza-5-(α-(Phenylmethylamino)Phenylmethyl)-2,6-Dioxobicyclo(5.4.0)Undecan-8-Yl)Glycyl-Isoleucyl-Argininyl Chloromethyl Ketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific activity assays. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.