Description

1-(5-Isoquinolinesulfonyl)-3-Methylpiperazine Hydrochloride is a high-purity chemical building block and research compound, primarily utilized as a key intermediate in pharmaceutical synthesis. Its core value lies in enabling the development of novel therapeutic agents, particularly those targeting specific enzymatic pathways. This product is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active molecules.
• Biochemical Research: Used as a tool compound or precursor in enzymatic studies and signal transduction pathway research.
• Organic Synthesis: Serves as a versatile sulfonamide-containing scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(5-Isoquinolinesulfonyl)-3-Methylpiperazine Hydrochloride
CAS No.	141543-65-9
Molecular Formula	C14H18ClN3O2S
Molecular Weight	327.83 g/mol
Synonyms	3-Methyl-1-(5-isoquinolinesulfonyl)piperazine hydrochloride; 1-(Isoquinolin-5-ylsulfonyl)-3-methylpiperazine hydrochloride; 3-Methyl-1-(5-isoquinolinylsulfonyl)piperazine HCl; 1-(5-Isoquinolinesulfonyl)-3-methylpiperazine HCl; H-1152 dihydrochloride (common research alias); PI3K inhibitor intermediate; Isoquinoline-5-sulfonamide derivative
EINECS	Contact for details

Quality Control

Our 1-(5-Isoquinolinesulfonyl)-3-Methylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.