Description

1-(5-Isoquinolinesulfonyl)Piperazine Hydrochloride is a high-purity organic building block and biochemical reagent of significant interest in pharmaceutical research and development. This compound serves as a key intermediate in the synthesis of more complex molecules, particularly those targeting specific enzymatic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and biochemical assay development. The material is supplied with stringent quality control to ensure consistency and reliability for sensitive applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitor research.
• Biochemical Research: Used as a tool compound or precursor in enzymatic studies and the development of high-throughput screening assays.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological processes and protein function.

Basic Information

Product Name	1-(5-Isoquinolinesulfonyl)Piperazine Hydrochloride
CAS No.	141543-63-7
Molecular Formula	C₁₃H₁₆ClN₃O₂S
Molecular Weight	313.80 g/mol
Synonyms	1-(Isoquinolin-5-ylsulfonyl)piperazine hydrochloride; 5-(Piperazine-1-sulfonyl)isoquinoline hydrochloride; Piperazine, 1-(5-isoquinolinesulfonyl)-, hydrochloride; 1-(5-Isoquinolinesulfonyl)piperazine HCl; Isoquinoline-5-sulfonyl piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(5-Isoquinolinesulfonyl)Piperazine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure traceability and consistency, with specifications aligned with common requirements for pharmaceutical intermediates and biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.