Description

Apaziquone is a synthetic indolequinone derivative with significant biological activity. This compound is valued for its role as a bioreductive prodrug, designed to be activated under hypoxic conditions, which is a key characteristic of many solid tumors. It is primarily utilized by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions focused on oncology and novel therapeutic mechanisms. The product is supplied to the global market under stringent quality controls to ensure reliability for critical research and development applications.

Application

• Oncology Research: As a key intermediate or active pharmaceutical ingredient (API) in the development of novel chemotherapeutic agents targeting hypoxic tumor cells.
• Prodrug Development: Serving as a model compound in studies focused on bioreductive activation pathways and targeted drug delivery systems.
• Biochemical Research: Used in laboratory studies to investigate mechanisms of action involving DNA alkylation and cytotoxicity under low-oxygen conditions.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and safety profiles of potential anticancer therapies.
• Reference Standard: Sourced for use as an analytical standard in quality control (QC) and method development within pharmaceutical analysis laboratories.

Basic Information

Product Name	Apaziquone
CAS No.	141304-51-0
Molecular Formula	C15H17N3O4
Molecular Weight	303.32 g/mol
Synonyms	EO9; EO-9; NSC 382051; 3-Hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione)propanol; 1-Methyl-2-(3-hydroxy-5-aziridin-1-ylmethyl-1-methylindole-4,7-dione)propan-1-ol; Apaziquone (USAN); Indoloquinone EO9
EINECS	Contact for details

Quality Control

Our Apaziquone is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Standard testing includes identification, assay (purity), and control of specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results and methods is provided with each batch to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.