Description

D-Fructose-2,5-13C2 is a stable isotope-labeled analog of fructose, specifically enriched with carbon-13 at the 2 and 5 positions. This compound is essential for advanced metabolic research and analytical method development, providing a critical tracer for precise quantification and pathway elucidation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutritional science, and biotechnology sectors who require high-purity isotopic standards for mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• Metabolic Flux Analysis (MFA): Used as a carbon-13 tracer to study carbohydrate metabolism, glycolysis, and the pentose phosphate pathway in cell cultures and biological systems.
• Quantitative Mass Spectrometry (MS): Serves as an internal standard for the accurate quantification of fructose and related metabolites in complex biological matrices like blood, urine, and tissue samples.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in isotope dilution studies to track the absorption, distribution, metabolism, and excretion (ADME) of sugar-based pharmaceuticals.
• Nutritional Research: Facilitates studies on dietary sugar uptake, fructose metabolism disorders, and the development of diagnostic assays.
• NMR Spectroscopy: Provides a site-specific isotopic label for structural analysis and dynamic studies of sugar-protein interactions.
• Biochemical Reagent Manufacturing: Incorporated into the production of high-value diagnostic kits and calibrated reagents for clinical and research laboratories.

Basic Information

Product Name	D-Fructose-2,5-13C2
CAS No.	141258-84-6
Molecular Formula	C6H12O6 (with 13C at positions 2 & 5)
Molecular Weight	182.15 g/mol (for 13C2 isotopologue)
Synonyms	Fructose-2,5-13C2; (2,5-13C2)-D-Fructose; D-(-)-Fructose-2,5-13C2; Levulose-2,5-13C2; Fruit sugar-2,5-13C2; 2,5-13C2-Fructose; [2,5-13C2]Fructose; β-D-Fructopyranose-2,5-13C2
EINECS	Contact for details

Quality Control

Our D-Fructose-2,5-13C2 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and specific analytical results. We adhere to rigorous in-house standards suitable for analytical and research grade materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (at positions 2 & 5)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	-90° to -94° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.