Description

Qs 21 CAS NO 141256-04-4 is a highly purified saponin-based adjuvant, specifically a triterpene glycoside, designed to enhance the efficacy of vaccine formulations. Its core value proposition lies in its ability to significantly potentiate both humoral and cellular immune responses, making it a critical component in advanced vaccine development. This product is essential for biopharmaceutical companies and research institutions focused on next-generation vaccines for infectious diseases, cancer immunotherapy, and other therapeutic applications.

Application

• Vaccine Adjuvant: A key immunostimulant in subunit, recombinant protein, and peptide-based vaccine formulations to enhance antigen-specific antibody and T-cell responses.
• Infectious Disease Research: Used in preclinical and clinical research for vaccines targeting influenza, HIV, malaria, and other pathogens requiring robust immune priming.
• Oncology Immunotherapy: Incorporated into therapeutic cancer vaccine candidates to break immune tolerance and stimulate cytotoxic T-lymphocyte activity against tumor cells.
• Veterinary Vaccines: Employed in high-value animal health vaccines to improve protection and reduce antigen dose.
• Immunology Studies: A standard tool in immunological research to study mechanisms of adjuvant action, antigen presentation, and immune cell activation.
• Formulation Development: Serves as a benchmark adjuvant in the development and optimization of novel vaccine delivery systems, including liposomes and emulsions.

Basic Information

Product Name	Qs 21
CAS No.	141256-04-4
Molecular Formula	C92H150O55
Molecular Weight	~1990.0 g/mol
Synonyms	QS-21; QS21; Quillaja Saponin 21; Quil A derivative; Saponin adjuvant QS-21; Triterpenoid saponin QS21; Vaccine adjuvant QS-21; (3β,4α,16α)-3-[[6-Deoxy-4-O-(6-deoxy-α-L-mannopyranosyl)-α-L-mannopyranosyl]oxy]-16-hydroxy-23-oxoolean-12-en-28-oic acid 28-[[6-Deoxy-4-O-(6-deoxy-α-L-mannopyranosyl)-α-L-mannopyranosyl]oxy] ester
EINECS	Contact for details

Quality Control

Our Qs 21 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for advanced pharmaceutical intermediates, ensuring the material meets the stringent requirements for immunology and vaccine development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may degrade the product. For long-term stability, store desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Endotoxin (LAL)	< 10 EU/mg
Sterility (for specific grades)	Sterile or Low Bioburden (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.