Description

7-Oxostaurosporine is a key derivative of the potent protein kinase inhibitor staurosporine, widely utilized as a critical reference standard and biochemical tool in pharmaceutical research and development. This compound matters for its role in studying kinase inhibition mechanisms and as a precursor for synthesizing more selective kinase inhibitors. It is primarily needed by research scientists and process chemists in the pharmaceutical, biotechnology, and academic sectors for drug discovery programs and analytical method development.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and for quality control in the production of kinase-targeted therapeutics.
• Biochemical Research: Serves as a crucial tool compound in enzymatic assays to study the activity and selectivity profiles of various protein kinases.
• Drug Discovery & Medicinal Chemistry: Acts as a versatile synthetic intermediate or a core scaffold for the design and development of novel, more selective kinase inhibitor candidates.
• Academic Research: Employed in university and institutional labs to investigate cellular signaling pathways, apoptosis, and cancer biology.
• Process Chemistry & Scale-up: Used in the development and optimization of synthetic routes for complex pharmaceutical active ingredients.

Basic Information

Product Name	7-Oxostaurosporine
CAS No.	141196-69-2
Molecular Formula	C28H26N4O4
Molecular Weight	482.53 g/mol
Synonyms	7-Oxo-staurosporine; UCN-01 7-Oxo analog; Antibiotic UCN-01 7-Oxo derivative; 7-Oxo-UCN-01; 8,9,13,14-Tetrahydro-14-methyl-7-oxo-8,21-epoxy-8-aza-8,21-seco-1H,7H-dipyrrolo[2,3-c:2',3'-l][1,7,12,16]tetraazacyclooctadecine-5,10,15,20(21H)-tetrone; 7-Oxo K252c; Staurosporine 7-one
EINECS	Contact for details

Quality Control

Our 7-Oxostaurosporine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95.0%
Assay	≥97.0% (on dried basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.