Description

Matlystatin B CAS NO 140923-32-6 is a potent and selective inhibitor of matrix metalloproteinases (MMPs), a class of enzymes involved in tissue remodeling and degradation. This compound is of significant interest in biochemical research for its ability to modulate extracellular matrix dynamics and cellular signaling pathways. It serves as a critical research tool for scientists in oncology, neurology, and inflammation research, enabling the study of disease mechanisms and the development of novel therapeutic strategies.

Application

• Biomedical Research: Used as a selective inhibitor to study the role of specific matrix metalloproteinases (MMPs) in cancer metastasis, angiogenesis, and tumor microenvironment regulation.
• Neurological Studies: Applied in research models to investigate MMP involvement in neuroinflammatory conditions, blood-brain barrier integrity, and neurodegenerative diseases.
• Inflammation and Immunology: Employed to elucidate the mechanisms of inflammatory diseases such as arthritis, atherosclerosis, and chronic wounds where MMP activity is dysregulated.
• Drug Discovery & Development: Serves as a reference compound or lead structure in high-throughput screening and medicinal chemistry programs aimed at developing new MMP-targeted therapies.
• Cell Biology and Tissue Engineering: Utilized to control extracellular matrix degradation in in vitro cell culture systems, facilitating studies on cell migration, invasion, and 3D tissue model development.

Basic Information

Product Name	Matlystatin B
CAS No.	140923-32-6
Molecular Formula	C30H48N4O7
Molecular Weight	576.73 g/mol
Synonyms	Matlystatin B; FR 901277; (2S,3S)-3-[(2S)-2-[(2S,3S)-3-[(2S)-2-[(2S,3S)-3-Amino-2-hydroxybutanoyl]amino-3-methylbutanoyl]amino-2-hydroxybutanoyl]amino-3-methylbutanoyl]amino-2-hydroxy-N-[(1S,2R)-1-hydroxy-2-methylpentyl]butanamide; MMP Inhibitor FR901277
EINECS	Contact for details

Quality Control

Our Matlystatin B is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.