Description

Macro-Prep 50Q is a high-capacity, strong anion exchange chromatography resin designed for the purification of biomolecules. This product is essential for achieving high-resolution separation and scalable purification in downstream bioprocessing. It is a critical tool for biopharmaceutical manufacturers, research institutions, and CROs/CMOs involved in the production of proteins, monoclonal antibodies, vaccines, and nucleic acids.

Application

• Monoclonal Antibody (mAb) Purification: For polishing steps to remove host cell proteins, DNA, viruses, and aggregates.
• Vaccine Production: Purification of viral vectors, recombinant antigens, and other vaccine components.
• Protein Therapeutics: Isolation and purification of enzymes, hormones, growth factors, and other therapeutic proteins.
• Nucleic Acid Purification: Suitable for the purification of plasmid DNA, mRNA, and oligonucleotides.
• Diagnostic Reagent Manufacturing: Purification of key proteins and enzymes used in diagnostic kits and assays.
• Process Development & Scale-Up: Ideal for optimizing purification protocols from laboratory scale to commercial manufacturing.

Basic Information

Product Name	Macro-Prep 50Q
CAS No.	140876-37-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Macro-Prep Q; MacroPrep 50 Q; Quaternary ammonium strong anion exchanger; Q Sepharose analog; Strong Anion Exchange (SAX) resin; Quaternary aminoethyl methacrylate resin; Polymer-based anion exchange media; Bio-Rad Macro-Prep 50Q
EINECS	Contact for details

Quality Control

Our Macro-Prep 50Q is manufactured under a quality management system and undergoes rigorous testing to ensure batch-to-batch consistency for critical process parameters. Each lot is tested for key performance attributes including dynamic binding capacity, particle size distribution, and flow properties. Certificates of Analysis (COA) documenting these specifications are available upon request to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at 15-25°C in a dry, well-ventilated area. The resin is supplied as a suspension in an appropriate storage solution; do not allow the resin to dry out. Keep away from strong oxidizing agents.

Specification

Item	Specification
Matrix	Methacrylate copolymer
Functional Group	Quaternary ammonium (Q)
Particle Size	50 μm (mean)
Dynamic Binding Capacity*	> 70 mg BSA/mL resin
pH Stability	2 - 12 (working)
Maximum Pressure	0.3 MPa (3 bar, 43 psi)
Storage Solution	20% Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.

*Capacity is molecule-dependent. Value provided is a typical reference for Bovine Serum Albumin (BSA).