Description

2,4-Bis(Trifluoromethyl)Benzyl Bromide is a high-value organobromine building block characterized by its reactive benzyl bromide group flanked by two electron-withdrawing trifluoromethyl substituents. This unique structure makes it a critical intermediate for introducing the lipophilic and metabolically stable bis(trifluoromethyl)benzyl moiety into more complex molecules. It is essential for research and development chemists in the pharmaceutical and agrochemical sectors who require precise, high-purity intermediates for synthesizing advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of compounds targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for specialized phosphine or nitrogen-based ligands used in transition metal catalysis, including cross-coupling reactions.
• Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry and discovery research for constructing diverse fluorinated compound libraries to explore structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Benzyl Bromide
CAS No.	140690-56-8
Molecular Formula	C10H5BrF6
Molecular Weight	319.05 g/mol
Synonyms	α-Bromo-2,4-bis(trifluoromethyl)toluene; 1-(Bromomethyl)-2,4-bis(trifluoromethyl)benzene; (2,4-Bis(trifluoromethyl)phenyl)methyl bromide; 2,4-Bis(trifluoromethyl)benzylbromide; 2,4-Bis(trifluoromethyl)benzyl bromide; 2,4-Di(trifluoromethyl)benzyl bromide; Benzene, 1-(bromomethyl)-2,4-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2,4-Bis(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is provided with each shipment. We support compliance with relevant regulatory frameworks for our customers' target markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.