Description

2-Aza-2-Desamino-5,8-Dideazafolic Acid is a specialized folate analog with significant research and development applications. This compound is valued for its role as a key intermediate and reference standard in the synthesis and study of novel chemotherapeutic agents and enzyme inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology and metabolic pathway research. The consistent quality and reliable supply of this material are critical for advancing high-value discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antifolate drugs and targeted cancer therapies.
• Biochemical Research: Used as a reference standard and inhibitor in studies of dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Academic & Discovery Chemistry: Serves as a scaffold for medicinal chemistry programs aimed at developing new enzyme inhibitors.
• Analytical Standard: Employed in HPLC, LC-MS, and NMR for method development, calibration, and purity assessment in quality control laboratories.
• Preclinical Development: Utilized in in vitro and in vivo studies to investigate pharmacokinetics and mechanism of action.

Basic Information

Product Name	2-Aza-2-Desamino-5,8-Dideazafolic Acid
CAS No.	140410-01-1
Molecular Formula	C₁₉H₂₁N₅O₆
Molecular Weight	415.40 g/mol
Synonyms	5,8-Dideaza-2-aza-2-desaminofolic Acid; 2-Aza-2-desamino-5,8-dideazapteroic Acid; DDATHF Analog; 2-Aza-5,8-dideazafolic Acid; Lometrexol Intermediate; AG2034 Related Compound; Antifolate Intermediate; NSC 680410
EINECS	Contact for details

Quality Control

Our 2-Aza-2-Desamino-5,8-Dideazafolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity reference standards and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.