Description

5-Chlorowillardiine is a synthetic derivative of the natural excitatory amino acid willardiine, specifically engineered with a chlorine substituent to modulate its biological activity. This compound is a valuable research-grade chemical, primarily serving as a selective agonist for specific subtypes of ionotropic glutamate receptors. It is essential for researchers and developers in the fields of neuroscience and pharmacology. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical experimental and developmental work.

Application

• Neuroscience Research: Used as a selective pharmacological tool to study the function and distribution of kainate and AMPA subtypes of glutamate receptors in the central nervous system.
• Drug Discovery & Development: Serves as a key reference compound and a structural template for the design and screening of novel neuroactive pharmaceuticals targeting neurological disorders.
• Biochemical Assays: Employed in in vitro receptor binding studies and functional assays to characterize receptor-ligand interactions and signal transduction pathways.
• Academic & Institutional Research: A critical reagent for universities and research institutes conducting fundamental studies on synaptic transmission, neurotoxicity, and neuronal plasticity.
• Preclinical Studies: Utilized in animal models to investigate the physiological and pathological roles of specific glutamate receptor subtypes.

Basic Information

Product Name	5-Chlorowillardiine
CAS No.	140187-24-2
Molecular Formula	C7H6ClN3O4
Molecular Weight	231.59 g/mol
Synonyms	5-Chloro-1H-pyrimidine-2,4-dione-6-acetic acid; 5-Chlorowillardine; (S)-2-Amino-5-chlorouracil-6-acetic acid; 5-Chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-6-acetic acid; 5-Chloro-DL-willardiine; 5-Chlorowillardiine (research grade)
EINECS	Contact for details

Quality Control

Every batch of 5-Chlorowillardiine is produced and analyzed under a strict quality management system to ensure the highest standards of purity and identity for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed results for identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.