Description

Dl-Threo-Ppmp (Hydrochloride) is a potent and selective inhibitor of glucosylceramide synthase (GCS), a key enzyme in glycosphingolipid biosynthesis. This compound matters for researchers investigating lysosomal storage disorders, such as Gaucher's disease, and for exploring the role of glycosphingolipids in cell signaling, oncology, and neurodegeneration. It is primarily needed by pharmaceutical R&D teams, academic researchers in biochemistry and cell biology, and developers of therapeutic agents targeting sphingolipid metabolism.

Application

• Biochemical Research: Used as a critical tool to inhibit glucosylceramide synthase and study glycosphingolipid metabolism and function in cellular models.
• Disease Mechanism Studies: Applied in research focused on lysosomal storage disorders, particularly Gaucher's disease, to understand pathology and evaluate potential treatment strategies.
• Oncology Research: Investigated for its effects on cancer cell proliferation, drug resistance, and apoptosis by modulating ceramide and sphingolipid pathways.
• Neuropharmacology: Utilized in studies exploring the role of sphingolipids in neuronal development, function, and in neurodegenerative conditions like Parkinson's and Alzheimer's disease.
• Drug Discovery: Serves as a reference compound or lead structure in the development of novel therapeutics targeting sphingolipid-related pathways.
• Cell Biology: Employed to manipulate glycosphingolipid levels on cell surfaces to study their role in cell adhesion, recognition, and signal transduction.

Basic Information

Product Name	Dl-Threo-Ppmp (Hydrochloride)
CAS No.	139974-41-7
Molecular Formula	C17H28N2O3 • HCl
Molecular Weight	352.88 g/mol (free base: 316.42)
Synonyms	DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride; PDMP hydrochloride (DL-threo isomer); 1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride (DL-threo); DL-threo-PPMP HCl; Glucosylceramide Synthase Inhibitor (DL-threo); GCS Inhibitor III; (±)-threo-PPMP hydrochloride; 3-Morpholino-1-phenyl-2-(palmitoylamino)-1-propanol hydrochloride (DL-threo)
EINECS	Contact for details

Quality Control

Our Dl-Threo-Ppmp (Hydrochloride) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, impurity profile, and physical characteristics. We adhere to high standards suitable for research and development applications, ensuring reliable and reproducible performance for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.