Description

Azidobestatin is a potent and selective inhibitor of aminopeptidase N (APN/CD13), a zinc-dependent metalloprotease. This compound is a critical research tool for studying the role of APN in biological processes such as angiogenesis, tumor cell invasion, and immune regulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, immunology, and protease inhibitor discovery.

Application

• Biochemical Research: A key reagent for investigating the enzymatic activity and biological function of aminopeptidase N (APN/CD13) in vitro and in cell-based assays.
• Oncology Studies: Used to probe the role of APN in tumor angiogenesis, metastasis, and cell proliferation, supporting the development of novel anti-cancer therapeutics.
• Immunology Research: Employed to study APN's function in antigen presentation, T-cell activation, and inflammatory responses.
• Protease Inhibitor Screening: Serves as a reference standard or positive control in high-throughput screening campaigns for identifying new APN inhibitors.
• Mechanistic Studies: Facilitates the elucidation of APN's role in peptide hormone processing, neuropeptide degradation, and pain signaling pathways.
• Vascular Biology: Applied in research exploring endothelial cell migration and capillary tube formation, processes where APN is implicated.

Basic Information

Product Name	Azidobestatin
CAS No.	139915-04-1
Molecular Formula	C20H28N6O4
Molecular Weight	416.48 g/mol
Synonyms	N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine Azide; Bestatin Azide; Azido-Bestatin; APN Inhibitor Azidobestatin; CD13 Inhibitor Azidobestatin; (2S,3R)-3-Amino-2-hydroxy-N-[(1S)-1-azido-4-methyl-1-oxopentan-2-yl]-4-phenylbutanamide
EINECS	Contact for details

Quality Control

Our Azidobestatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.