Description

(+)-D-Threo-Pdmp (Hydrochloride) is a high-purity, enantiomerically pure chemical compound widely used as a potent and selective inhibitor of glucosylceramide synthase (GCS). This targeted action makes it a critical research tool for studying glycosphingolipid metabolism and its role in various disease pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disorder research, lysosomal storage disease studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: A key tool for investigating the biosynthesis and function of glycosphingolipids (GSLs) in cell biology.
• Pharmacology Studies: Used to validate glucosylceramide synthase as a drug target in preclinical models for diseases like Gaucher's disease, Fabry disease, and certain cancers.
• Neuroscience Research: Employed in studies exploring the role of GSLs in neuronal development, function, and neurodegenerative conditions.
• Cell Signaling Pathways: Applied to dissect the involvement of ceramide and its metabolites in apoptosis, autophagy, and cellular stress responses.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in related pharmaceutical analysis.
• Drug Discovery & Development: Used as a lead compound or comparator in screening assays for novel GCS inhibitors.

Basic Information

Product Name	(+)-D-Threo-Pdmp (Hydrochloride)
CAS No.	139889-62-6
Molecular Formula	C23H32ClNO3 • HCl
Molecular Weight	442.42 g/mol (for hydrochloride salt)
Synonyms	(+)-D-Threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol Hydrochloride; D-threo-PDMP hydrochloride; (2S,3R)-1-Phenyl-2-(decanoylamino)-3-morpholin-4-ylpropan-1-ol hydrochloride; PDMP hydrochloride; Glucosylceramide Synthase Inhibitor; GCS Inhibitor; DL-threo-PDMP (enantiomerically pure form); 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol HCl
EINECS	Contact for details

Quality Control

Our (+)-D-Threo-Pdmp (Hydrochloride) is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be aligned with specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.