Description

Depudecin is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes, specifically targeting Class I HDACs. This compound is a critical research tool for studying epigenetic regulation, cellular differentiation, and gene expression in various biological systems. It is primarily utilized by researchers and developers in the fields of pharmaceutical R&D, biotechnology, and academic life sciences for investigating cancer biology, neurodegenerative diseases, and other conditions linked to epigenetic dysregulation.

Application

• Biochemical Research: A key reagent for in vitro studies of HDAC enzyme activity and inhibition mechanisms.
• Cell Biology & Epigenetics: Used to induce hyperacetylation of histones in cell culture models to explore effects on gene transcription and cellular phenotype.
• Cancer Research: Investigated for its potential to inhibit proliferation and induce differentiation or apoptosis in various cancer cell lines.
• Neuroscience Research: Applied in models to study the role of HDACs in neuronal development, synaptic plasticity, and neurodegenerative disorders.
• Stem Cell Research: Utilized to modulate the epigenetic state and influence the differentiation pathways of stem cells.
• Drug Discovery: Serves as a reference compound and a starting point for the development of novel HDAC-targeted therapeutics.

Basic Information

Product Name	Depudecin
CAS No.	139508-73-9
Molecular Formula	C₁₅H₂₂O₄
Molecular Weight	266.33 g/mol
Synonyms	(-)-Depudecin; FR-901375; (2R,3S,4S,5E,7S,8S,9R)-2,9-Dihydroxy-3,4:7,8-diepoxy-undeca-5,10-diene; HDAC Inhibitor VIII; (2R,3S,4S,5E,7S,8S,9R)-2,9-Dihydroxy-3,4:7,8-diepoxyundeca-5,10-diene; (1R,2S,3S,6E,8S,9S,10R)-4,11-Dioxatricyclo[8.2.0.0²,⁹]dodeca-5,11-diene-6,10-diol
EINECS	Contact for details

Quality Control

Our Depudecin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems are designed to support research and development needs with reliable, well-characterized materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, ethanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.