Description

Mertansine CAS NO 139504-50-0 is a potent cytotoxic maytansinoid derivative widely used as a payload in the development of antibody-drug conjugates (ADCs). Its primary value lies in its ability to selectively target and destroy cancer cells when linked to a tumor-specific monoclonal antibody, thereby minimizing systemic toxicity. This compound is essential for pharmaceutical R&D teams, biotech companies, and contract manufacturing organizations (CMOs) focused on advancing next-generation targeted cancer therapies.

Application

• Primary payload in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Key intermediate in pharmaceutical research for developing novel oncology treatments.
• Used in preclinical and clinical studies to evaluate the efficacy of new ADC constructs.
• Critical component in the manufacturing of bioconjugates under current Good Manufacturing Practice (cGMP) standards.
• Research tool for studying microtubule inhibition and its effects on cell division.
• Reference standard for analytical method development and quality control in ADC production.

Basic Information

Product Name	Mertansine
CAS No.	139504-50-0
Molecular Formula	C35H48ClN3O10S
Molecular Weight	738.28 g/mol
Synonyms	DM1; Emtansine; Maytansinoid DM1; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; mertansine; NSC-330507; Ansamitocin P-3 derivative
EINECS	Contact for details

Quality Control

Our Mertansine is manufactured and tested to meet the stringent requirements for advanced pharmaceutical intermediates. Each batch undergoes comprehensive analytical characterization, including HPLC purity and identity confirmation (IR, MS). We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with relevant regulatory frameworks for drug substance development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.