Description

13(S)-Hode-D4 is a deuterium-labeled analog of the bioactive lipid mediator 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE). This stable isotope-labeled compound is an essential tool for precise quantitative analysis and metabolic pathway tracing in biochemical research. It is primarily utilized by researchers and analytical laboratories in the pharmaceutical, biotechnology, and academic sectors for advanced mass spectrometry-based studies, including lipidomics, biomarker discovery, and drug metabolism investigations.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative internal standard for the accurate measurement of endogenous 13(S)-HODE levels in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in tracer studies to elucidate the biosynthesis, turnover, and metabolic fate of oxylipins and related eicosanoid signaling molecules.
• Biomarker Research & Validation: Enables the development and validation of highly sensitive and specific assays for 13(S)-HODE, a biomarker associated with inflammation, oxidative stress, and various disease states.
• Pharmaceutical R&D: Facilitates pharmacokinetic and pharmacodynamic studies in drug development programs targeting lipoxygenase pathways or inflammatory disorders.
• Lipidomics Profiling: A key component in targeted lipidomics panels for comprehensive profiling of oxidized linoleic acid metabolites (OXLAMs) in research.
• Enzyme Activity Assays: Employed as a substrate or reference compound in assays for lipoxygenase and other related enzyme activities.

Basic Information

Product Name	13(S)-Hode-D4
CAS No.	139408-39-2
Molecular Formula	C18H28D4O3
Molecular Weight	~296.45 g/mol
Synonyms	13(S)-HODE-d4; (13S)-13-Hydroxy-9Z,11E-octadecadienoic-9,10,12,13-d4 acid; 13S-Hydroxyoctadeca-9Z,11E-dienoic-9,10,12,13-d4 acid; 13(S)-HODE (9,10,12,13-d4); Deuterated 13(S)-HODE; 13(S)-HODE tetradeuterated; 13S-Hydroxy-9Z,11E-octadecadienoic-d4 acid; 13(S)-HODE Internal Standard
EINECS	Contact for details

Quality Control

Our 13(S)-Hode-D4 is manufactured under strict quality-controlled conditions to ensure high chemical and isotopic purity, which is critical for reliable analytical results. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Assay)	≥ 95%
Specific Rotation	Contact for details
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.