Description

Phenylalanylarginine Fluoromethyl Ketone is a potent and selective fluorinated peptide-based inhibitor designed for targeted protease research. This compound is critical for biochemical studies requiring high specificity and activity, enabling precise investigation of enzyme mechanisms and pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery, proteomics, and enzyme kinetics studies.

Application

• Protease Inhibition Research: Serves as a key biochemical tool for studying the activity and inhibition of specific serine or cysteine proteases.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for developing novel therapeutic agents targeting proteolytic enzymes.
• Mechanistic Enzymology: Enables detailed kinetic and structural analysis of enzyme-substrate interactions and catalytic mechanisms.
• Biomarker & Diagnostic Assay Development: Acts as a reference standard or inhibitor in the development of clinical diagnostic tests for disease-related protease activity.
• Academic & Institutional Research: Supports fundamental biological research in cell signaling, apoptosis, and protein processing pathways.
• Biopharmaceutical Production: May be employed in process development to control or study protease activity during fermentation and purification.

Basic Information

Product Name	Phenylalanylarginine Fluoromethyl Ketone
CAS No.	139323-38-9
Molecular Formula	C20H30FN5O4
Molecular Weight	423.49 g/mol
Synonyms	Phe-Arg-FMK; Phenylalanyl-Arginine Fluoromethyl Ketone; Z-Phe-Arg-FMK; Z-Phe-Arg-CH2F; Benzyloxycarbonyl-Phe-Arg-FMK; Caspase Inhibitor; Fluoromethyl Ketone Inhibitor; Protease Inhibitor 139323-38-9
EINECS	Contact for details

Quality Control

Our Phenylalanylarginine Fluoromethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.