Description

Kn-93 CAS NO 139298-40-1 is a potent, cell-permeable, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). This compound matters as a critical pharmacological tool for elucidating the role of CaMKII in cellular signaling pathways, particularly in neuroscience and cardiovascular research. It is needed by researchers and pharmaceutical developers in the fields of neurobiology, cardiology, and molecular biology for studying mechanisms related to synaptic plasticity, memory, cardiac hypertrophy, and arrhythmias.

Application

• Neuroscience Research: Used to investigate CaMKII's role in synaptic plasticity, long-term potentiation (LTP), learning, and memory formation.
• Cardiovascular Research: Employed in studies of cardiac signaling, including pathways involved in hypertrophy, heart failure, and arrhythmias.
• Cellular Signaling Studies: Serves as a selective tool to dissect CaMKII-mediated signaling cascades in various cell types.
• Drug Discovery & Development: Used in target validation and screening assays for developing novel therapeutics targeting CaMKII-related disorders.
• Biochemical Assays: Applied in in vitro kinase assays to determine the specificity and potency of CaMKII inhibition.
• Disease Mechanism Elucidation: Aids in research on conditions where CaMKII dysregulation is implicated, such as ischemia-reperfusion injury and certain neurological diseases.

Basic Information

Product Name	Kn-93
CAS No.	139298-40-1
Molecular Formula	C₂₆H₂₇N₅O₂
Molecular Weight	441.52 g/mol
Synonyms	KN-93; KN93; 2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine; N-[2-[[[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide; CaMKII Inhibitor KN-93; CaMKII Inhibitor II
EINECS	Contact for details

Quality Control

Our Kn-93 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.