Description

Piericidin B1 n-Oxide is a chemically modified derivative of the natural product Piericidin B1, characterized by the addition of an N-oxide functional group. This compound is of significant interest in biochemical and pharmacological research due to its role as a potent and specific inhibitor of mitochondrial complex I (NADH:ubiquinone oxidoreductase). It serves as a critical research tool for scientists and institutions investigating cellular respiration, bioenergetics, and the mechanisms of metabolic diseases. Its primary applications are found in advanced life science research, including studies on neurodegenerative disorders, cancer metabolism, and the development of novel agrochemicals.

Application

• Mitochondrial Research: As a specific inhibitor of mitochondrial complex I, it is used to study electron transport chain function, oxidative phosphorylation, and ATP production in cell cultures and isolated mitochondria.
• Neurodegenerative Disease Models: Employed in research models for Parkinson's disease and other disorders linked to mitochondrial dysfunction and oxidative stress.
• Cancer Metabolism Studies: Used to investigate the Warburg effect and the reliance of certain cancer cells on glycolysis by inhibiting oxidative phosphorylation.
• Insecticide & Agrochemical Research: Serves as a reference compound or lead structure in the development of new insecticides, given the structural similarity of piericidins to natural insecticidal compounds.
• Biochemical Assay Development: Utilized as a standard or control in high-throughput screening assays designed to identify novel modulators of mitochondrial function.
• Toxicology & Safety Assessment: Applied in studies assessing the cellular toxicity of chemicals that may impair mitochondrial activity.

Basic Information

Product Name	Piericidin B1 n-Oxide
CAS No.	139182-76-6
Molecular Formula	C25H39NO5
Molecular Weight	433.59 g/mol
Synonyms	Piericidin B1 N-Oxide; 2,6-Dimethoxy-3,5-dimethyl-4-(3-methyl-1-oxido-5-{2-[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]pyridin-1-ium-1-yl}pentyl)phenol; 1-Hydroxy-2,6-dimethoxy-3,5-dimethyl-4-(3-methyl-5-{2-[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]pyridin-1-ium-1-yl}pentyl)pyridin-1-ium; Piericidin B1 Oxide
EINECS	Contact for details

Quality Control

Our Piericidin B1 n-Oxide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment and structural confirmation. Certificates of Analysis (COA) detailing specific test results for identity, purity, and impurities are provided with every shipment. We support research compliance, and our quality systems are designed to meet the stringent requirements of pharmaceutical and academic research laboratories.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is light-sensitive (store away from light) and should be allowed to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.