Description

n-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Acetamide (Tamibarotene) is a synthetic retinoid derivative with potent biological activity, primarily known for its selective agonism of retinoic acid receptors. This compound is of significant commercial and research interest due to its targeted mechanism of action, which offers advantages over broader-spectrum retinoids. It is a critical active pharmaceutical ingredient (API) and a valuable pharmacological research tool for investigating cell differentiation and proliferation pathways. The product is supplied under strict quality control to ensure consistency for pharmaceutical development and advanced life science applications.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of targeted oncology therapeutics.
• Biochemical Research as a selective RARα/β agonist for studying retinoic acid signaling pathways.
• Preclinical Development of treatments for acute promyelocytic leukemia (APL) and other malignancies.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Cell Biology Studies to investigate mechanisms of cell differentiation, proliferation, and apoptosis.
• Drug Discovery as a lead compound or comparator in the development of novel retinoid-based therapies.

Basic Information

Product Name	n-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Acetamide (Tamibarotene)
CAS No.	139162-43-9
Molecular Formula	C22H29NO
Molecular Weight	323.47 g/mol
Synonyms	Tamibarotene; Am 80; 4-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic Acid (related acid form); Benzoic acid, 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)carbamoyl]-; AM-080; NSC 726189
EINECS	Contact for details

Quality Control

Our Tamibarotene is manufactured and tested to meet high-purity standards suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We adhere to a cGMP-compliant quality management system to ensure traceability and batch-to-batch consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.