Description

Lexipafant is a potent and selective platelet-activating factor (PAF) receptor antagonist, a key compound in advanced pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, making it a critical tool for investigating inflammatory pathways and related therapeutic interventions. This high-purity compound is essential for researchers and manufacturers in the global pharmaceutical, biotechnology, and academic sectors focused on developing novel anti-inflammatory agents and studying complex cellular signaling processes.

Application

• Pharmaceutical R&D: Primary active pharmaceutical ingredient (API) or key intermediate in the development of novel anti-inflammatory and immunomodulatory drugs.
• Biochemical Research: A selective tool compound for in vitro and in vivo studies of platelet-activating factor (PAF) receptor biology and signal transduction pathways.
• Mechanism of Action Studies: Used to elucidate the role of PAF in various disease models, including sepsis, acute pancreatitis, asthma, and anaphylaxis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Critical for pharmacokinetic, pharmacodynamic, and toxicology studies during the drug discovery pipeline.

Basic Information

Product Name	Lexipafant
CAS No.	139133-26-9
Molecular Formula	C26H29N5O4
Molecular Weight	475.54 g/mol
Synonyms	BB-882; UK-74,505; (R)-2-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]propanamide; 2-[(4R)-4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]propanamide; Lexipafantum; PAF Antagonist BB-882
EINECS	Contact for details

Quality Control

Our Lexipafant CAS NO 139133-26-9 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities to meet exacting research-grade standards. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.