Description

Tyrphostin B48 is a potent and selective small-molecule inhibitor of the platelet-derived growth factor receptor (PDGFR) tyrosine kinase. This compound is a critical research tool for investigating signal transduction pathways, cellular proliferation, and angiogenesis. It is primarily utilized by researchers and scientists in the fields of oncology, cardiovascular disease, and cell biology for target validation, biochemical assays, and in vitro studies.

Application

• Biochemical Research: Used as a selective PDGFR tyrosine kinase inhibitor in enzymatic assays to study kinase activity and inhibition mechanisms.
• Cell Biology Studies: Applied in cell culture models to investigate the role of PDGFR signaling in cell proliferation, migration, and differentiation.
• Oncology Research: A valuable tool for exploring the therapeutic potential of PDGFR inhibition in various cancer models, including gliomas and sarcomas.
• Angiogenesis Research: Employed to study the effects of PDGFR pathway modulation on blood vessel formation and related pathologies.
• Signal Transduction Pathway Analysis: Facilitates the mapping of downstream signaling events triggered by PDGFR activation.
• Pharmaceutical Development: Serves as a reference compound or lead structure in the discovery and development of novel kinase-targeted therapeutics.

Basic Information

Product Name	Tyrphostin B48
CAS No.	139087-53-9
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 1296; Tyrphostin AG 1296; 6,7-Dimethoxy-2-phenylquinazolin-4(3H)-one; PDGFR Tyrosine Kinase Inhibitor AG1296; 6,7-Dimethoxy-2-phenyl-3H-quinazolin-4-one; AG-1296; (6,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenylmethanone
EINECS	Contact for details

Quality Control

Our Tyrphostin B48 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure high batch-to-batch consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.