Description

L-689,560 is a potent and selective glycine/NMDA receptor antagonist, widely recognized in neuroscience research. This compound is crucial for studying the role of NMDA receptors in synaptic plasticity, neuroprotection, and various neurological disorders. It is an essential tool for pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and basic neuropharmacology.

Application

• Neuroscience Research: A key pharmacological tool for investigating the function and modulation of NMDA receptors, particularly those containing the NR2B subunit.
• Mechanistic Studies: Used to elucidate pathways involved in excitotoxicity, long-term potentiation (LTP), and long-term depression (LTD).
• Drug Discovery Screening: Serves as a reference standard and active comparator in high-throughput screening assays for novel neuroprotective or cognitive-enhancing agents.
• Preclinical Model Development: Employed in animal models to study conditions such as stroke, traumatic brain injury, epilepsy, and chronic pain.
• Biochemical Assays: Used in in vitro binding and functional assays to characterize receptor-ligand interactions and downstream signaling.

Basic Information

Product Name	L-689,560
CAS No.	139051-78-8
Molecular Formula	C18H21N3O4S
Molecular Weight	375.44 g/mol
Synonyms	(±)-4-(4-Phenyl-2-carboxypiperazin-1-yl)-7-(phosphonomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid; L 689560; L-689,560; MDL 105,519; (RS)-4-(4-Phenyl-2-carboxypiperazin-1-yl)-7-(phosphonomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid; 1,2,3,4-Tetrahydro-7-(phosphonomethyl)-4-(4-phenyl-2-piperazinylcarbonyl)isoquinoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-689,560 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.