Description

Capsazepine CAS NO 138977-28-3 is a potent and selective competitive antagonist of the vanilloid receptor subtype 1 (TRPV1). This compound is a critical research tool for investigating the role of capsaicin-sensitive pathways in pain, inflammation, and neurogenic responses. It is essential for pharmaceutical R&D, academic research, and the development of novel analgesic and anti-inflammatory therapeutics targeting the TRP channel family.

Application

• Neuroscience Research: A key pharmacological tool for studying TRPV1 receptor function, pain signaling, and thermal nociception.
• Drug Discovery & Development: Used as a reference standard and screening agent in the development of novel TRPV1 antagonists for pain management.
• Inflammatory Pathway Analysis: Employed in research models to elucidate the role of neurogenic inflammation and capsaicin-evoked responses.
• Academic & Clinical Research: Fundamental for in vitro and in vivo studies exploring sensory neuron biology and potential therapeutic interventions.
• Biochemical Assays: Used in receptor binding studies and functional assays to characterize ligand-receptor interactions at TRPV1.

Basic Information

Product Name	Capsazepine
CAS No.	138977-28-3
Molecular Formula	C19H21ClN2O2
Molecular Weight	344.84 g/mol
Synonyms	Capsazepine; N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide; TRPV1 Antagonist; Vanilloid Receptor Antagonist; CPZ
EINECS	Contact for details

Quality Control

Our Capsazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.