Description

(1S,2S)-o-Demethyl Tramadol Glucuronide is a major, pharmacologically relevant metabolite of the analgesic tramadol. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism, pharmacokinetic studies, and forensic toxicology. It serves as a vital reference standard for analytical laboratories, enabling the accurate quantification and validation of tramadol and its metabolites in biological matrices. Professionals in pharmaceutical R&D, contract research organizations (CROs), and forensic science rely on this high-purity standard to ensure data integrity and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for calibrating analytical instruments and validating methods in drug testing.
• Metabolite Profiling & PK/PD Studies: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) of tramadol in preclinical and clinical research.
• Forensic Toxicology: Used as a calibrant or control in confirmatory testing (e.g., LC-MS/MS, GC-MS) for the accurate identification of tramadol use in forensic and workplace drug testing.
• Bioanalytical Method Development: A key component in developing and optimizing sensitive and specific assays for tramadol metabolites in plasma, urine, and other biological samples.
• Quality Control in Manufacturing: Employed in the quality control laboratories of pharmaceutical manufacturers to monitor impurity profiles and ensure batch consistency.
• Academic & Clinical Research: Supports investigative studies on opioid metabolism, pharmacogenomics, and drug-drug interactions involving tramadol.

Basic Information

Product Name	(1S,2S)-o-Demethyl Tramadol Glucuronide
CAS No.	138853-75-5
Molecular Formula	C23H31NO9
Molecular Weight	465.5 g/mol
Synonyms	(1S,2S)-O-Desmethyltramadol Glucuronide; O-Demethyl Tramadol Glucuronide (1S,2S-isomer); Tramadol Metabolite M5; (+)-O-Desmethyltramadol β-D-Glucuronide; 2-[(1S,2S)-2-[(Dimethylamino)methyl]-1-hydroxycyclohexyl]phenyl β-D-Glucopyranosiduronic Acid; UNII-6V4Q2R5J4F; O-Desmethyltramadol Glucuronide
EINECS	Contact for details

Quality Control

Our (1S,2S)-o-Demethyl Tramadol Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to in-house primary standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is light-sensitive (store away from light). Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.