Description

Hoe 140, Desarg(10)- CAS NO 138680-92-9 is a potent and selective synthetic peptide antagonist of the bradykinin B2 receptor. This compound is a critical research tool for investigating the physiological and pathological roles of the kallikrein-kinin system. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in cardiovascular, inflammatory, and pain-related research. Its high specificity makes it invaluable for target validation and mechanistic studies in drug discovery.

Application

• Pharmacological Research: As a standard reference antagonist for studying bradykinin-mediated signaling pathways in vitro and in vivo.
• Drug Discovery & Development: For target validation and screening assays aimed at developing novel anti-inflammatory, analgesic, or cardioprotective agents.
• Cardiovascular Research: Investigation of bradykinin's role in blood pressure regulation, vascular permeability, and ischemic preconditioning.
• Inflammation & Pain Studies: Elucidation of kinin system involvement in inflammatory diseases, neuropathic pain, and edema.
• Biochemical Assay Development: Used as a control compound in receptor binding assays and functional cellular tests.
• Academic & Institutional Research: Fundamental research into G-protein coupled receptor (GPCR) biology and peptide pharmacology.

Basic Information

Product Name	Hoe 140, Desarg(10)- CAS NO 138680-92-9
CAS No.	138680-92-9
Molecular Formula	C₆₀H₈₉N₁₉O₁₄S
Molecular Weight	1300.5 g/mol
Synonyms	Icatibant; Hoe-140; D-Arg-[Hyp³,Thi⁵,D-Tic⁷,Oic⁸]-Bradykinin; B2 Receptor Antagonist; Bradykinin B2 Antagonist; Des-Arg¹⁰-[D-Arg⁰,Hyp³,Thi⁵,D-Tic⁷,Oic⁸]-Bradykinin; (R)-1-[[2,3-Dihydro-1-oxo-1H-1-isoindolyl]carbonyl]-L-prolyl-3-(2-thienyl)-L-alanyl-4-hydroxy-N-[[[[[1-[[(4-methylphenyl)sulfonyl]amino]cyclopentyl]carbonyl]oxy]methyl]-L-phenylalanyl-L-argininamide
EINECS	Contact for details

Quality Control

Our Hoe 140 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.