Description

Bisindolylmaleimide Viii Acetate Salt CAS NO 138516-31-1 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC) isoforms, widely utilized as a critical research tool in biochemical and pharmacological studies. Its primary value lies in enabling precise investigation of PKC-mediated signaling pathways, which are central to understanding cellular processes like proliferation, differentiation, and apoptosis. This high-purity biochemical is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on oncology, neuroscience, and metabolic disease research.

Application

• Biochemical Research: A key tool for studying the role of Protein Kinase C (PKC) in signal transduction pathways.
• Pharmaceutical R&D: Used in target validation and screening assays for developing novel therapeutics targeting PKC-related diseases.
• Oncology Studies: Investigates PKC's involvement in cancer cell proliferation, survival, and metastasis.
• Neuroscience Research: Explores PKC signaling in neuronal function, synaptic plasticity, and neurodegenerative conditions.
• Cell Biology: Employed to modulate PKC activity in cell culture models to dissect specific cellular responses.
• Enzyme Inhibition Studies: Serves as a reference standard for evaluating the selectivity and potency of new PKC inhibitors.

Basic Information

Product Name	Bisindolylmaleimide Viii Acetate Salt
CAS No.	138516-31-1
Molecular Formula	C23H21N3O2 • C2H4O2
Molecular Weight	439.48 g/mol
Synonyms	Bisindolylmaleimide VIII; BIM VIII; Ro 31-8220; 3-[1-[3-(Amidinothio)propyl]-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide methanesulfonate; Protein Kinase C Inhibitor VIII; PKC Inhibitor VIII; 2-[1-(3-Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide methanesulfonate
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide Viii Acetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.