Description

Ro-31-8220 is a potent, cell-permeable, and selective protein kinase C (PKC) inhibitor with significant research utility. Its primary value lies in its ability to selectively modulate PKC activity, a key enzyme family involved in numerous signal transduction pathways. This compound is essential for researchers in pharmacology, biochemistry, and cell biology studying cellular signaling, apoptosis, and cancer mechanisms.

Application

• Biochemical Research: A critical tool for investigating the role of Protein Kinase C isoforms in signal transduction cascades.
• Cell Signaling Studies: Used to inhibit PKC activity in cell culture models to elucidate its function in proliferation, differentiation, and apoptosis.
• Neuroscience Research: Applied in studies of neurotransmitter release, synaptic plasticity, and neuronal survival where PKC plays a modulatory role.
• Oncology Research: Employed to probe PKC's involvement in tumor promotion, cell survival, and as a potential target for therapeutic intervention.
• Cardiovascular Research: Utilized in models studying PKC's effects on cardiac function and vascular tone.
• Inflammatory Response Analysis: Helps define the contribution of PKC to immune cell activation and inflammatory mediator production.

Basic Information

Product Name	Ro-31-8220
CAS No.	138489-18-6
Molecular Formula	C32H29N5O4
Molecular Weight	547.60 g/mol
Synonyms	Ro 31-8220; Ro318220; 3-[1-[3-(Amidinothio)propyl]-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX; PKC Inhibitor Ro-31-8220; 3-(1-(3-(Amidinothio)propyl)-1H-indol-3-yl)-3-(1-methyl-1H-indol-3-yl)maleimide methanesulfonate
EINECS	Contact for details

Quality Control

Our Ro-31-8220 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.